Inhibition of mitogen activated protein kinase interacting kinase (MNK), the kinase that specifically phosphorylates eIF4E, suppresses ectopic activity in human sensory neurons recovered from individuals with radicular neuropathic pain 58, and attenuates nociceptive behaviors in rodents with neuropathic pain 59–61. The gene discussed is EIF4E; the disease is neuropathic pain.