IGHE and allergic rhinitis: Dysbiosis of the intestinal flora, on the one hand, will cause the bacteria colonizing the intestinal tract to stimulate the human immune system with ligands such as lipopolysaccharides, flagellin and fatty acids, which will activate the immune system and lead to the activation of naïve T-cells and the production of Th1, Th2, and Th17 (103), which will in turn affect the mast cells and other cells, which will produce degranulation changes that will lead to an increase in the production of IgE, thus leading to the onset and progression of allergic rhinitis (104, 105).