The System Xc–/GSH/GPX4 axis, DHODH–ubiquinol (CoQH2) system, FSP1–CoQ10 axis, GTP cyclohydrolase-1 (GCH1)–tetrahydrobiopterin (BH4) axis, and sex hormones can inhibit ferroptosis, and the inhibition of related molecular pathways is an important strategy to induce ferroptosis in tumor cells (45). Here, GCH1 is linked to neoplasm.