Recent studies have shown that the lncRNA 00312/miR-34a-5p/ASS1 axis reduces proliferation and invasion and promotes apoptosis in RCC (113), and that the SNHG12/SP1/CDCA3 ferroptosis-related long non-coding RNA (FRIncRNA) axis promotes RCC progression and sunitinib resistance, thereby serving as a new target for the treatment of sunitinib-resistant RCC (114). This evidence concerns the gene SP1 and renal cell carcinoma.