To study the effect of LCN2 on the development of other types of classic lupus organ involvement besides the brain, MRL/lpr and MRL/lpr LCN2-KO mice were evaluated for the extent and severity of skin disease using validated scores for alopecia, erythema, and skin thickening of the back and face (27). The gene discussed is LCN2; the disease is systemic lupus erythematosus.