TWIST1: transcription factor promoting tumor cell invasion and metastasis, as well as metastatic recurrence;MMPs: the breakdown of extracellular matrix in normal physiological processes (embryonic development, reproduction, and tissue remodeling);CD44: a cell-surface glycoprotein involved in cell-cell interactions;INPP5A: mobilizing Intracellular calcium and acts as a second messengerCD147: immunoglobulin in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The gene discussed is INPP5A; the disease is neoplasm.