CD28 and mastitis: Consistent evidence supported the causal effects of CD28- CD8dim %CD8dim on mastitis across MR Egger (OR = 1.047, 95% CI = 1.013~ 1.082, p = 0.018), Weighted median (OR = 1.051, 95% CI = 1.013~ 1.090, p = 0.009) and Weighted mode methods (OR = 1.054, 95% CI = 1.017~ 1.092, p = 0.011).