In contrast, overexpression of PXR may induce pro-inflammatory effects and produce AD-like inflammation as transgenic mice constitutively expressing human PXR in basal keratinocytes (K14-VPPXR mice) exhibited AD-like features such as skin barrier impairment, increased serum IgE, and increased Th2/Th17 skin immune responses (18). Here, IGHE is linked to Alzheimer disease.