Finally, on January 1989 he was diagnosed as HAE-C1INH type I (C1-INH antigen: 0.02 g/L; normal range: 0.21-0.38 g/L; Functional C1INH activity:10%; normal range: 70-130%; C4: 0.03g/L; normal range 0. The gene discussed is SERPING1; the disease is hereditary angioedema.