Furthermore, we found that inhibition of ETFDH by siRNA or by CRISPR/Cas9 mediated knock‐out was sufficient to also reduce JunB expression levels hereby connecting reduced JunB expression and responsiveness to LPS to the genotype of MADD patients (Figure 2M,N and Figure S3). Here, ETFDH is linked to multiple acyl-CoA dehydrogenase deficiency.