Wnt/β-catenin signaling has been associated with organ fibrosis. Nuclear β-catenin recruits CBP or p300 to stimulate the transcription of its target genesTGFβ stimulates COL1A2 transcription via functional cooperation between Smad3 and p300/CBP transcriptional coactivatorsThe HIF-1α-p300/CBP complex binds to the hypoxia response element (HRE) to activate the transcription of genes involved in fibrogenesis. The gene discussed is EP300; the disease is fibrosis.