On-going in vivo studies are currently being conducted in our laboratory to test the effect of NGR1 on blood glucose level using more than one dose, compare the activity of NGR1 to known antidiabetic agents such as sulphonylureas or GLP-1 agonists, identify the underlying mechanism(s) and pathway(s) by which NGR1 might alleviate glucose intolerance. Here, RTN4R is linked to Glucose intolerance.