NFATC1 and osteoporosis: Additionally, some researchers have demonstrated that the prevention of osteoporosis in mice lacking estrogen is achieved through the inhibition of Pdk2, which likely works by diminishing irregular activation of osteoclasts, potentially through the suppression of the nuclear factor-κB ligand (RANKL)-CREB-cFOS-nuclear factor of activated T cells 1 (Nfatc1) signaling pathway (Lee et al., 2021).