Li et al. [43] established a rat model of disuse osteoporosis (DOP) by tail suspension and found that mechanical stress unloading decreased lncRNA H19 expression and promoted Dkk4 expression, which inhibited the Wnt signaling and ultimately led to reduced bone formation and DOP, suggesting that lncRNA H19 may be regulated by mechanical stress. The gene discussed is H19; the disease is osteoporosis.