A previous in vivo investigation found that by upregulating the PI3K-Akt-CREB signaling pathway and the mRNA and protein expressions of TRKB, PI3K, Akt, CREB, and IGF2, SSF may enhance cognitive impairment and neurogenesis in AD model rats (Liu Q. Q. et al., 2022). Here, AKT1 is linked to Alzheimer disease.