AKT1 and Alzheimer disease: Drug treatment is an important option for AD patients; however, only a few medications are authorized for use in therapeutic settings, such as galantamine, memantine, donepezil, rivastigmine, and the Chinese herb extract huperzine A. Given the function of the PI3K-Akt pathway in AD, several synthetic and natural modulators, ranging from chemicals to herbs, have been shown to alleviate the symptoms of this degenerative condition in various in vivo and in vitro models.