The panel also has GGCX, whose pathogenic variants were first linked to multiple vitamin K-dependent clotting factor deficiency (VKCFD1; OMIM #277450), an autosomal recessive disorder characterized by a mild to severe bleeding tendency and a predisposition to thrombotic events (Brenner et al., 1998). The gene discussed is GGCX; the disease is vitamin K-dependent clotting factors, combined deficiency of, type 1.