Patients with or without PE and high NT-proBNP (>1000 ng/L) had poor outcome in this study, which is consistent with previous studies.2 Pathophysiology for elevated NT-proBNP levels in patients with PE include increase in pulmonary vascular resistance and afterload of the right ventricle (RV) followed by RV dilatation, leading to the release of NT-proBNP. Here, NPPB is linked to Vascular dilatation.