Among patients with PE, only the NT-proBNP tended to improve predictive power when compared to a baseline model including age, sex, and cancer, with AUC values of 86.7 (95% CI 78.7–94.8) and 81.8 (95% CI 72.9–90.6, P = 0.071, respectively, N = 157). Here, NPPB is linked to cancer.