We co-cultured T cells with PXDN overexpressed NPC cells and found that PXDN overexpression inhibited T-cell proliferation and anti-tumor activation, as demonstrated by the decreased levels of the cytotoxic T cell marker (TNFα) and the increased expression of the suppressor T cell marker (TIM3) marker. The gene discussed is PXDN; the disease is nasopharyngeal carcinoma.