IL6 and cancer: One caveat, however, is the LNPs that coat the mRNA are by themselves immunostimulatory, acting as an adjuvant component, fostering T-follicular helper cells (Tfh cells) and humoral responses that are abrogated if Il-6 induction by the LNP is blocked using an antibody or using Il-6 deficient mice (55); the implications for cancer therapy in humans are unknown.