Within the targeted tumor, diverse cell populations add to the complexity of immunotherapeutic approaches, but recent data indicates that immune triads- a close interaction between DCs, CD4+ T cells, and CD8+ T cells, working synergistically, can dramatically eliminate solid tumors by reprogramming the CD8+ T cell to become functional and tumor cytolytic for a range of cancers (41). This evidence concerns the gene CD8A and neoplasm.