CD40LG and infection: In the multivariate analysis, having a higher comorbidity burden (⩾2 comorbidities, 1.62 [95% CI: 1.41–1.87]; one comorbidity, 1.36 [95% CI: 1.20–1.55]) and relapse activity before OCR treatment start (1.25 [95% CI: 1.11–1.41]) presented as the highest risk factors for all infections, while previously treated patients (1.14 [95% CI: 1.00–1.29]) and patients with IgM < LLN (1.18 [95% CI: 1.08–1.29]) showed a small increased risk.