FUS and proteostasis deficiencies: Proteinopathies that are commonly found in FTLD include tau inclusions (FTLD-Tau), TDP-43 inclusions (FTLD-TDP) or, rarely, inclusions of the FET protein family.59 Interestingly, the neuronal inclusions related to the neurodegenerative changes in our study exhibited predominantly aSyn pathology, with only few independent tau aggregates in the limbic system, that might be related to age or other early and mild limbic tauopathy, without TDP-43, FUS or Aß aggregates.