To the best of our knowledge, this is the first study demonstrating carriers of the CYP3A5*1 wildtype allele, the ABCC2 -24C>T T variant allele, and the ABCC2 3972C>T T variant allele were more cost-effective in lowering the risk of ATN and graft rejection among KTRs. This evidence concerns the gene CYP3A5 and oculocutaneous albinism type 1.