ACS, acute chest syndrome; HbSC, hemoglobin sickle C disease; HbSS, sickle cell anemia; PMN, polymorphonuclear neutrophil; SCD, sickle cell disease; sPLA2, secretory phospholipase A2; VOC, vaso-occlusive crises. The gene discussed is PLA2G2D; the disease is Schnyder corneal dystrophy.