However, most of these studies were carried out in diabetics [12-19], and even though efforts were made by excluding patients with diagnosis of gastroparesis and diabetic neuropathy [17-19], there could have been a significant number of patients with non-diagnosed or subclinical DGE that were missed and may have been minimally exacerbated by concomitant GLP-1 RA administration. This evidence concerns the gene GLP1R and diabetic neuropathy.