RCT: randomized controlled trial; DM: diabetes mellitus; STEMI: ST-segment elevation myocardial infarction; NSTEMI: non-ST-segment elevation myocardial infarction; MACE: major adverse cardiovascular event; ACS: acute coronary syndrome; T2DM: type 2 diabetes mellitus; LVMi: left ventricular mass index; MI: myocardial infarction; PCI: percutaneous coronary intervention; eGFR: estimated glomerular filtration rate; NT-proBNP: N-terminal pro-B-type natriuretic peptide; HbA1c: hemoglobin A1c; IGT: impaired glucose tolerance; CMR: cardiac magnetic resonance; CABG: coronary artery bypass grafting. The gene discussed is NPPB; the disease is acute coronary syndrome.