Objective: This study aimed to evaluate the differences between Alzheimer's disease (AD) patients and controls in biochemistry and peripheral hemogram parameters neutrophil, lymphocyte, monocyte, platelet, and C-reactive protein (CRP) levels, lipid profile, inflammatory burden index (IBI), and hemoglobin, albumin, lymphocyte, and platelet (HALP) score and the relationship between inflammatory and immunonutritive biomarkers and cognitive impairment in patients. The gene discussed is CRP; the disease is Cognitive impairment.