In more than 40% of these patients, pupillary abnormalities, oculomotor signs, and pseudobulbar manifestations can be observed [5]. As the ischemic stroke with the highest mortality rate, greater than 85%, the only proven treatment for BAO patients is recanalization with intravenous r-tPA, intra-arterial r-tPA, or endovascular treatment. With adequate treatment, a good outcome can be obtained in up to 35%, and the mortality can be dropped to 40% [4]. There is still no definite consensus on the treatment window as there are still few large-scale randomized trials focusing on BAO. This evidence concerns the gene PLAT and ischemic stroke.