In addition to its role in the DDR, USP28 was also demonstrated to stabilize the c-MYC oncogene by antagonizing its ubiquitin-mediated degradation by the ubiquitin ligase FBW7 that is frequently lost in cancers (Popov et al., 2007a; Popov et al., 2007b). The gene discussed is FBXW7; the disease is cancer.