GSVA results of PCOS showed that high expression of FAM166B was mainly enriched for O-glycan biosynthesis, glycosaminoglycan biosynthesis-chondroitin sulfate, fructose and mannose metabolism, Glycolysis/gluconeogenesis, amino sugar and nucleotide sugar metabolism and Glutathione metabolism signaling pathways (Figure 8A). The gene discussed is CIMIP2B; the disease is polycystic ovary syndrome.