LOX and cancer: The lysyl oxidase(LOX) protein family is known to promote cross-linking of key ECMproteins and is associated with desmoplasia in solid cancers.62 In particular, LOX mRNA is significantly overexpressedin patients, correlating with metastatic status and poor survival.63,64 The role of LOX in the cancer cultures is cell-type dependent, asthe matrix stiffening in ACHN models correlates with upregulationof LOX, however significant reduction in its gene expression was notobserved in matrix softening by 786-O cells.