IL2 and Erythema: IL-2-dependent immune amplification is suppressedsufficiently to keep cellular immune reactivity below a critical threshold.86,87 CsA was found to reduce the density of T-cell subsets in both thedermis and epidermis of psoriatic lesions.88 Attributed to the greater disposition of CsA within the psoriaticskin after CsA-CAGE-P gel application, the primary and secondary efficacystudy objectives of reduced erythema, scaling, and epidermal thicknesswere achieved.