Furthermore, it is associated with autosomal dominant polycystic kidney disease (ADPKD), where it contributes to disease progression, particularly through its involvement in renal interstitial inflammation and fibrosis [37].These findings underscore the critical roles of SUMO3 and CD74 in the pathogenesis of DKD fibrosis, offering valuable insights into their potential as therapeutic targets in fibrosis-related kidney diseases. The gene discussed is SUMO3; the disease is autosomal dominant polycystic kidney disease.