Lastly, through <i>TMTC1</i>-related gene enrichment analysis, some biological processes and pathways were found to be significantly enriched, such as vascular endothelial growth factor receptor signaling pathway and ECM-receptor interaction.<h4>Conclusions</h4>Our study demonstrates the prognostic significance of <i>TMTC1</i> in pan-cancer and highlights its potential as an immunotherapeutic target. The gene discussed is TMTC1; the disease is cancer.