Moreover, our analysis revealed that high expression of <i>TMTC1</i> was associated with worse overall survival (OS) outcomes in patients with ACC, BLCA, COAD, GBM, KIRP, OV, STAD, and UCEC, but better OS outcomes in patients with CESC, KIRC, LUSC, and PAAD. The gene discussed is TMTC1; the disease is adrenal cortex carcinoma.