M2-like macrophages can further promote GC cell proliferation, metastasis, and even the transformation of normal cells into cancer cells through various signaling pathways, including the TNF-α/NF-κB/HIF-1α/miR-210/NTN4 axis [34] and the TGFβ2/NF-κB/Kindlin-2 axis [35]. The gene discussed is NFKB1; the disease is cancer.