Another prognostic risk model for AML based on 12 FRGS, including 10 high-risk genes (GPX4, CD44, CISD1, SESN2, LPCAT3, AIFM2, AKR1C2, SOCS1, ACSL5 and HSPB1) and two protective genes (ACSL6 and G3BP1) (100), showed that these genes served an important role in regulating ferroptosis and tumor development (101). This evidence concerns the gene AIFM2 and neoplasm.