Numerous substances, including eprenetapopt (APR-246), aldehyde dehydrogenase 3 family member A2 (ALDH3A2), poly(lactic acid)-glycolic acid-encapsulated glycyrrhetinic acids (GCMNPs), glutathione-bioimprinted nanoparticles targeting of N6-methyladenosine FTO demethylase (GNPIPP12MA), gold nanorods (GnR) functionalized with chitosan and a 12-mer peptide 12 (GnRA-CSP12) and GCFN, have been found to induce ferroptosis in AML cells by disrupting the balance between GSH and ROS and inhibiting GPX4 synthesis (51,66–69). Here, ALDH3A2 is linked to acute myeloid leukemia.