A total of eight ferroptosis regulators PGD, ACSF2, CISD1, DPP4, GPX4ADDIN, SQLE, AIFM2 and CHAC1] were used to create a predictive model, and were all associated with poor prognosis in patients with AML (97,98). This evidence concerns the gene ACSF2 and acute myeloid leukemia.