Chemokines play a variety of roles in inflammation, immunity, injury repair, and other cellular responses, and CXCL16 has also been implicated in the progression of atherosclerosis46 and linked to an increased risk of MI.13 FGF-23 is involved in the regulation of phosphate and calcium homeostasis,47 and higher levels of this protein have been associated with several CVDs, including MI.13 Such sex-related disparities can be attributed to differences in sex hormones or sex hormone receptors, cardiovascular epigenetics,48 or metabolic and lifestyle risk factors in women and men. This evidence concerns the gene CXCL16 and myocardial infarction.