80). Similarly, DENV envelope domain III (EIII) also activated platelet, and caused thrombocytopenia in vivo primarily through NLRP3-mediated pyroptosis (Ref. 84). EIII also impaired clotting time, and interestingly, inhibition of this response pathway via NLRP3 inhibition or EIII blocking could significantly improve the conditions (Ref. 84). The gene discussed is NLRP3; the disease is Thrombocytopenia.