MSI1 and glioblastoma: ForNotch, MSI1 binding to Numb mRNA reduces translation and thereby upregulatesthe pathway favoring differentiation and proliferation.18 In addition to the two RRMs, MSI1 contains along C-terminal intrinsic disorder region (IDR).This region has been associated with protein aggregation19 and the formation of cellular condensates, suchas stress granules in glioblastoma, which have been correlated witha worse prognosis.20