LDHA and Parkinson disease: On the other hand, the expression levels of hexokinase 2 (HK2) and lactate dehydrogenase A (LDH-A) were increased in SNc DA neurons in the brain of MPTP-injected mouse model of PD, and also in MPP+-treated catecholaminergic SH-SY5Y cells (Li et al., 2022b).