Considering the function of DYRK1B in chemoresistance, it is important to understand the mechanism of DYRK1B upregulation, particularly in cancer cells that lack genetic amplification of DYRK1B. Like all kinases of the DYRK family, DYRK1B undergoes activation by autophosphorylation and maintains constitutive activity17,18. Here, DYRK1B is linked to cancer.