LAG3 and neoplasm: Pseudotime analysis showed that, in our tumor model, CD8+ T cells progressed from their naïve state to an interferon (IFN)-activated phenotype, with their evolution then directed either towards memory functions or to a short-lived fate with a phenotype presenting signs of exhaustion (Fig. 5B), including the expression of immune checkpoints as PD1 and LAG3 (Supplementary Fig. 3A).