Interestingly, we have previously shown increased muscle fibre and NMJ endplate sizes in TWEAK-depleted SOD1G93A ALS mice [33], further supporting a role for the TWEAK/Fn14 pathway in muscle pathology in this mouse model and in more general adult denervation-induced muscle atrophy [34]. The gene discussed is TNFSF12; the disease is amyotrophic lateral sclerosis.