We found that the expression of NF-κB subunit p50 was significantly upregulated in the TAs of SOD1G93A mice at both early symptomatic (Fig. 1C) and late symptomatic (Fig. 1D) time-points compared to WT animals, supporting an increased activity of TWEAK/Fn14 activity in skeletal muscle of ALS mice. Here, TNFRSF12A is linked to amyotrophic lateral sclerosis.