The expression of Nrf2 and its downstream ABCC1 in glioma patients’ tissues is positively correlated, which may be related to drug resistance and poor overall survival rate in GBM patients.178 Inducing ferroptosis may be an important therapeutic strategy to reverse drug resistance in GBM with high expression of Nrf2 and ABCC1. This evidence concerns the gene ABCC1 and central nervous system cancer.