Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes.493 Lipid peroxides and their reactive aldehyde derivatives are the key factors in cardiometabolic disorders in obesity, with GPX4 playing a crucial role. The gene discussed is GPX4; the disease is obesity due to melanocortin 4 receptor deficiency.