LEP and Insulin resistance: Iron overload is a key negative regulator of leptin and adiponectin.233,234 Iron overload causes a loss of adipocyte-specific FPN, further leading to iron overload in adipocytes, reduced adiponectin levels, and insulin resistance.233 The association between, low adiponectin levels, insulin resistance and adipocyte iron overload were also been proved in a mitochondrial ferritin (FtMt) overexpression model.235 These findings provide evidence of increased ROS, decreased adiponectin, insulin resistance, and glucose intolerance due to adipocyte iron overload.