KEAP1 and neoplasm: Diethyl fumarate (DMF), an activator of Nrf2, has been reported to reduce lipid peroxidation and inhibit hepatocyte ferroptosis, thereby ameliorating alcoholic hepatitis.328 Dehydroabietic acid, a tricyclic divalent resin acid isolated from coniferous plants, offers many benefits for the human body, including anti-tumor, antibacterial, anti-aging, and anti-inflammatory.329,330 It has been reported that dehydroabietic acid binding to Keap1 in hydroxide-induced MAFLD mice, promoting the expression of GSH, GPX4, and HO-1, thereby reducing ROS and MDA accumulation.