GPX4 and neurodegenerative disease: In this pathway, GPX4 also serves as a crucial regulator of ferroptosis.78 It was found that reduced GPX4 expression leads to increased lipid ROS levels and activation of ferroptosis.76 Conditional knockout of GPX4 causes death of mouse embryonic fibroblasts in a lipid peroxide-dependent, non-apoptotic form and causes neurodegenerative disease in the cortical regions and hippocampus of the mouse brain.80