MTOR and obesity due to melanocortin 4 receptor deficiency: Deficiency of skeletal muscle cystathionine γ-lyase leads to insulin resistance, ferroptosis, and obesity, resulting in hyperglycemia and skeletal muscle injury in high-fat diet mice.293 In obese mice, there is a marked increase in VEGF, and mammalian target of rapamycin (mTOR), oxidative stress, and ferroptosis within primordial follicles.294