ACSL4 and Hepatic steatosis: Bioinformatics analysis have identified associations between hepatic steatosis and ferroptosis-related genes such as AKR1C1, AKR1C2, ACSL3, ACSL4, CS, GSS, FADS2, and PGD.304 In MASH patients, ferroptosis-related genes like SLC40A1, ACSL5, CP, and SLC11A2 are downregulated, while ACSL4, ACSL6, ferritin light chain (FTL), and FTH1 are upregulated.302 This suggests that MAFLD progression involves iron overload, an imbalance in antioxidant defenses, and lipid peroxidation within in the ferroptosis signaling pathway.