Genetic ablation and/or pharmacological inhibition of FABP5 ameliorate the HCC burden in mice.308 The absence of EF-hand domain family member D2 (EFHD2), improves hepatic steatosis, reduces immune cell infiltration, suppresses ferroptosis caused by lipid peroxidation, and ultimately reduces MASH. Here, EFHD2 is linked to hepatocellular carcinoma.