PSEN1 and Alzheimer disease: In APP/PS1 mice, BBB permeability and pericyte number are reduced, and β-amyloid induces mitochondrial autophagy-dependent ferroptosis via the CD36/PINK/PARKIN pathway, resulting in blood-brain barrier damage and contributing to AD.565 The disturbance of iron homeostasis in the brain and ferroptosis of neurons can exacerbate neuroinflammation, causing abnormal microglial activation.