The GPR30 receptor agonist G1 inhibits ferroptosis and significantly improves chondrocyte viability and motor ability in mice through the YAP1/FTH1 pathway, while GPR30 receptor antagonist G15 has the opposite effect, suggesting that hormone-related ferroptosis may emerge as a promising target for alleviating osteoarthritis in postmenopausal women.863 NCOA4 mediated ferritinophagy plays a crucial role in regulating intracellular iron levels, and elevated expression of NCOA4 has been observed in the cartilage of OA patients, OA mice, and inflammatory chondrocytes. This evidence concerns the gene NCOA4 and osteoarthritis.