HIF1A and ischemic stroke: In the early stages of ischemic stroke, ACSL4 expression is suppressed, which is induced by HIF-1α.756 Overexpression of ACSL4 exacerbates cerebral I/R injury in rodents, while genetic or pharmacological reduction of ACSL4 effectively prevents cerebral I/R injury.756,757 The combination of circular RNA Carm1 and miR-3098-3p regulates the expression of ACSL4 and has a protective effect on acute cerebral infarction injury.758 cPLA2α is highly expressed in ischemic stroke patients and is positively correlated with injury degree and infarct size.