Mitochondrial pyruvate carrier 1 (MPC1), an inner membrane protein that transfers pyruvate into mitochondria, is differentially expressed in normal and cancer cells, and inhibition of MPC1 expression can prompt a shift towards EMT in cancer cells.99 The expression of MPC1 is regulated by histone lysine demethylase 5A (KDM5A), also referred to as RBP2 or JARID1A. This evidence concerns the gene KDM5A and cancer.