High-throughput sequencing and dual-luciferase reporter gene analysis show that exercise induces an increase of skeletal muscle exosomes and exosomal miR-484 could enter the brain through blood circulation to inhibit the expression of ACSL4 and thus inhibit ferroptosis of nerve cells.786 Exercise intervention before stroke that increases skeletal muscle-derived exosomes is also an effective treatment strategy for cerebral I/R injury. Here, ACSL4 is linked to stroke disorder.