Friedreich’s ataxia is characterized by alterations in lipid metabolism, resulting in the accumulation of intracellular lipids in the form of lipid droplets in fibroblasts from patients.437 Lipid droplet accumulation was observed in brown adipose tissue and heart in a mouse model of Friedreich’s ataxia, as well as in Frataxin-deficient rat cardiomyocytes and IPSC-derived cardiomyocytes.434,438 It is worth noting that Friedreich’s ataxia models are characterized by a significant increase in lipid peroxidation. This evidence concerns the gene FXN and Friedreich ataxia.