Ovarian cancer is a gynecological tumor with high morbidity and mortality.119 Agrimonolide dose-dependently increases intracellular ROS and iron levels, while decreasing SLC7A11 and GPX4 levels.120 Sterol CoA desaturase (SCD1) is a lipid regulatory enzyme that catalyzes the desaturation of saturated fatty acids to their Δ9-monounsaturated counterparts.121 Agrimonolide induces ferroptosis in ovarian cancer cells by inhibiting SCD1 protein translation and stability. This evidence concerns the gene GPX4 and ovarian cancer.