Overexpression of PPARα contributes to reducing PA-induced ferroptosis; oleoylethanolamide inhibits ferroptosis induced by hyperlipidemia and mitochondrial DNA damage, improving vascular sclerosis.275 Oxidized LDL was found to induce ferroptosis by inhibiting the activity of GPX4, and anti-ferroptosis treatment showed good therapeutic effects.276. This evidence concerns the gene GPX4 and hyperlipidemia.