In renal I/R injury, C3G increases GPX4 expression and GSH level, reverses excessive intracellular free iron accumulation, decreases lipid ROS, ACSL4, 4-HNE, and MDA levels, and significantly inhibits the ferroptosis of renal tubular cells.838 In addition, paeoniflorin, isoliquiritigenin, and curcumin have also been reported to alleviate I/R-induced acute kidney injury by inhibiting ferroptosis in renal tubule cells.839–841. Here, ACSL4 is linked to acute kidney injury.