RNA methylation, introduced at highly conserved sites by specific modification enzymes, is closely associated with the pathogenesis of cancer.122,123 METTL17 is a member of the methyltransferase family.124 METTL17 is upregulated in colorectal cancer, and the absence of METTL17 increases the sensitivity of colon cancer cells to ferroptosis, and promotes cell proliferation and the growth of transplanted tumors. The gene discussed is METTL17; the disease is colorectal cancer.