BMAL2 and lung adenocarcinoma: DpdtbA inhibits EMT by downregulating the proline hydroxylase 2/HIF-1α pathway and inducing ROS production through ferritinophagy.115 ARNTL2 is a circadian transcription factor, which has been shown to be involved in the pathogenesis of various tumors in recent years.116,117 ARNTL2 is highly expressed in patients with lung adenocarcinoma and has been shown to be an independent predictor of poor prognosis in these patients.