Mechanistically, there is a negative correlation between KLF2 and GPX4, and KLF2 deficiency increases the level of GPX4 and inhibits ferroptosis, promoting the invasion and migration of renal cancer cells, which can be reversed by overexpression of GPX4,150 indicating that promoting ferroptosis of cancer cells may be a promising strategy for the clinical treatment of advanced RCC. Here, GPX4 is linked to renal cell carcinoma.