Exercise interventions have been shown to help restore physical function after stroke and improve prognosis.784,785 Pre-stroke exercise intervention alleviates stroke-induced ferroptosis by reducing the production of LPO, upregulating GPX4 and SLC7A11, and downregulating ACSL4, thereby reducing the size of cerebral infarction and improving the neurological function of ischemic stroke rats. This evidence concerns the gene ACSL4 and ischemic stroke.