ACSL1 and cancer: Mechanistically, ACSL1 increases N-myristoylation of FSP1, inhibiting its degradation and promoting its membrane transfer, thereby counteracting oxidative stress-induced cellular ferroptosis.205 Following carboplatin treatment, ACSL1/FSP1 activation inhibits ferroptosis and reduces the sensitivity of cancer cells to platinum chemotherapy, promoting cell survival and metastasis.205 Shikonin is one of the main natural naphthoquinone compounds in dried roots of Lithospermum erythrorhizon.