The KDM5A-MPC1 signaling axis may enhance their sensitivity to ferroptosis inducers by regulating mitochondrial metabolism and EMT in cancer cells.100 Analysis of The Cancer Genome Atlas data showed that low MPC1 expression in head and neck cancer (HNC) tissues was associated with poor overall survival.101 KDM5A inhibition increases MPC1 expression and reduces the susceptibility of erlotinib-tolerant persistent head and neck cancer cells (erPCCs) to ferroptosis inducers. The gene discussed is KDM5A; the disease is cancer.