GPX4 and rheumatoid arthritis: Therefore, the ferroptosis fundamental characteristics, that is, GPX4 inactivation, GSH depletion, iron deposition, and lipid peroxidation, have garnered attention in the context of RA pathogenesis.341 Gene regulatory network analysis based on FLSs, a key target of damage in RA disease, has identified major transcription factors involved in fatty acid metabolism and ferroptosis.342