The RNA-binding protein SND1 binds to the 3’UTR of HSPA5, destabilizing HSPA5 mRNA, thereby inhibiting GPX4 and promoting ferroptosis in osteoarthritis.868 P21 significantly affects the recruitment of GPX4 to the linear ubiquitin chain assembly complex and plays an important role in anti-ferroptosis in OA by regulating the stability of GPX4.869 FOXO3 attenuates OA progression by promoting the SLC7A11/GPX4 pathway and inhibiting the NF-κB/MAPK pathway, thus inhibiting ferroptosis and extracellular matrix degradation in chondrocytes.870. Here, GPX4 is linked to osteoarthritis.