In addition, mitoglitazone significantly alleviates renal I/R injury in mice by upregulating GPX4 and reducing iron-related lipid peroxidation.836 Quercetin blocks the typical morphological changes of ferroptosis by decreasing MDA and lipid ROS levels and increasing GSH levels, thereby improving I/R-induced acute kidney injury. The gene discussed is GPX4; the disease is acute kidney injury.