Wnt agonists or ferroptosis inhibitors can reverse the typical Wnt signaling inhibition induced by iron overload and restore osteoblast differentiation by reducing ROS and LPO production.890 Iron-dependent lipid peroxidation contributes to the development of diabetes-related osteoporosis.891,892 Overexpression of FtMt reduces ferroptosis in osteoblasts induced by high glucose, while silence FtMt induces mitochondrial autophagy through the ROS/PINK1/Parkin pathway, thereby inducing ferroptosis in osteoblasts.893 This may be one of the important mechanisms of diabetes-induced osteoporosis. This evidence concerns the gene PRKN and osteoporosis.