IREB2 and Parkinson disease: BJP-IVb prevents PD by inhibiting iron regulatory protein (IRP2) from iron overload-mediated ferroptosis in dopaminergic neurons, as demonstrated by diminished lipid peroxidation and reduced iron content.606 By activating autophagy and inhibiting ferroptosis, rapamycin reduces the loss of dopamine neurons in the substantia nigra and improves behavioral symptoms in PD model mice, suggesting that the mutual regulation of ferroptosis and autophagy may provide therapeutic targets for drug therapy of PD.607