SIRT1, a target in the inflammatory response of articular chondrocytes is activated by curcumin, which protects chondrocytes by inhibiting MMP-13 and NF-κB expression.362 Pomegranate-derived polyphenols alleviate RA by inhibiting the activation of MMP-13, simultaneously blocking the anti-inflammatory signaling pathway, and activating the antioxidant defense system in chondrocytes.363 Furthermore, icariin has been found to inhibit ferroptosis in synovial cells and exert a protective effect through activation of the Xc−/GPX4 axis.364. Here, GPX4 is linked to rheumatoid arthritis.