Increased advanced glycosylation end products in a high-glucose environment also affects osteoblast differentiation and function.894 Acid sphingomyelinase (ASM)-mediated autophagy activation is critical for hyperglycemia -induced GPX4 degradation, and inhibition of ASM improves osteogenic function by reducing hyperglycemia-induced GPX4 degradation and subsequent ferroptosis.895. Here, GPX4 is linked to Hyperglycemia.