Macrophage-mediated iron release can promote muscle regeneration, while selective inhibition of macrophage iron output can inhibit muscle regeneration and cause fat accumulation.919 The latest bioinformatics analysis identified 11 key genes associated with sarcopenia, including FOXO1, HSPB1, MDH2, CDKN1A, and DLD, which are closely related to ferroptosis in sarcopenia.920 In addition, differences in immune cell infiltration were observed between normal and sarcopenia samples. Here, MDH2 is linked to sarcopenia.