Ferroptosis of myocytes induced by lipid peroxidation accumulation and iron overload through the p53/SLC7A11 pathway is crucial in sarcopenia’s pathogenesis and can be used as a potential intervention target for intervention.377 Iron overload reduces the phosphorylation of FOXO3a and AKT in skeletal muscle, and increases the expression of muscle atrophy-associated E3 ubiquitin ligase muscle ring finger-1 and atrogin-1.918 Inhibition of FOXO3a or oxidative stress reverses iron overload-induced muscle atrophy by reactivating the AKT-FOXO3a pathway.918. This evidence concerns the gene FOXO3 and sarcopenia.