ACSL4 and metabolic dysfunction-associated steatohepatitis: Knocking down ACSL4 also remarkably reduces the levels of 5-hydroxyeicosatetraenoic acid (5-HETE) thereby reducing arsenic-induced MASH.302,327 Another study demonstrated that troglitazone inhibits ferroptosis induced by erastin.317 However, no clinical trials have been conducted to evaluate the therapeutic effects of troglitazone and/or rosiglitazone on MAFLD through inhibiting ferroptosis.302