CDH2 and cancer: During EMT, E-cadherin expression decreases, while N-cadherin expression increases.92,93 Ferroptosis and EMT have a complicated interaction, which is mediated by multiple signaling pathways.94 Cancer cells undergoing EMT may have greater sensitivity to ferroptosis, and cancer cells with mesenchymal characteristics are generally more vulnerable to ferroptosis than cancer cells with epithelial properties.90,95