FXN and Friedreich ataxia: Desmyter et al. found that overexpression of FTL extended the lifespan of Frataxin-deficient yeast by preventing oxidative stress and iron accumulation.430 These findings suggest that iron metabolism is abnormal in the cells of Friedreich’s Ataxia models, and regulation of iron metabolism may have some ameliorative effects on Friedreich’s Ataxia.