PRKN and Parkinson disease: In the PD model, DR-AB, an antibody that targets the DR region of the NKA-α subunit, disrupts the cytoplasmic interaction between NKA-α1 and Parkin, promotes Parkin translocation to mitochondria, and enhances mitochondrial autophagy.610 In addition, DR-AB enhances the formation of the cell membrane NKA-α1 /SLC7A11 complex and inhibits SLC7A11-dependent ferroptosis.610