The mechanism may be related to curculigoside significantly reducing AD-promoting factors (e.g., Aβ1-42, p-tau) and increasing ferroptosis protective factors (e.g., GPX4, SLC7A11, GSH) in the hippocampus and cortex of AD mice,574 suggesting that the natural compound curculigoside can be used as a promising therapeutic agent to improve AD by inhibiting ferroptosis. Here, GPX4 is linked to Alzheimer disease.