Bladder cancer has become the most common malignancy of the urinary system, and there is currently no effective treatment strategy for invasive bladder cancer.127,164,165 Heat shock protein family A (HSP70) member 5 (HSPA5) is abnormally expressed in various tumors, closely related to tumor progression and prognosis.166–168 The expression of HSPA5 increases in bladder cancer and correlates with patient prognosis. This evidence concerns the gene HSPA5 and urinary bladder carcinoma.