Mitochondrial pyruvate carrier 1 (MPC1), an inner membrane protein that transfers pyruvate into mitochondria, is differentially expressed in normal and cancer cells, and inhibition of MPC1 expression can prompt a shift towards EMT in cancer cells.99 The expression of MPC1 is regulated by histone lysine demethylase 5A (KDM5A), also referred to as RBP2 or JARID1A. The gene discussed is PROS1; the disease is cancer.