Emodin can relieve collagen-induced joint inflammation in rats by inhibiting ferroptosis and degrading MMP.365 Large leukotrienes relieve RA via the Nrf2/HO-1/GPX4 pathway.366 Haloperidol affects T lymphocytes in RA patients by altering the DNA replication program, DNA damage response, and ferroptosis.367 Moxibustion improves the inflammatory response in synovial tissue of RA model rats, potentially through its regulation of ferroptosis-related factors. Here, NFE2L2 is linked to rheumatoid arthritis.