Pharmacological inhibition of SLC7A11 significantly causes tumor regression of PDAC and eliminates MCU-driven metastasis, suggesting that SLC7A11 may be a downstream target of the MCU-Nrf2 axis.162,163 Paradoxically, despite enhanced cystine uptake, MCU-overexpressed PDAC exhibited typical features of ferroptosis caused by cystine deprivation. This evidence concerns the gene MCU and neoplasm.