NFE2L2 and cardiomyopathy: Nrf2 can activate the transcription of a series of antioxidant genes and block ferroptosis, playing a protective role in DOX-induced cardiomyopathy by regulating oxidative stress and autophagy.487–489 However, these findings appear to contradict Fang’s results.490 Fang found DOX increased Nrf2 nuclear accumulation, promoted the expression of HO-1, and caused heme degradation, and led to the rapid and systematic accumulation of free non-heme iron.