This reveals that the METTL17-mediated defense mechanism against ferroptosis may serve as a potential therapeutic target for colon cancer.125 Tagitinin C, a sesquiterpene lactone derived from gentian, induces oxidative cellular microenvironment that triggers ferroptosis in colon cancer cells and inhibits cancer cell growth.126 The ferroptosis induced by Tagitinin C is characterized by a decrease in GSH and an increase in lipid peroxidation. The gene discussed is METTL17; the disease is cancer.