GPX4 and Parkinson disease: Clausenamide, an alkaloid isolated from Clausena lansium, interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment.608 Morroniside activates the Nrf2/ARE pathway, upregulates GPX4, SLC7A11, FTH1, and FPN expression, increases GSH content, and decreases MDA and iron levels.