Emerging evidence suggests a link between ferroptosis and MAFLD progression.302 Elevated hepatic iron levels may lead to MAFLD and promote the progression of the disease, with excessive iron content may increase hepatocyte swelling, inflammation, and fibrosis, potentially converting isolated steatosis to MASH.303 Moreover, hepatic iron accumulation can induce the transcription expression of ACSL4 by activating the transcription factor c-Myc, and further aggravate the development of MASH through ferroptosis. Here, ACSL4 is linked to metabolic dysfunction-associated steatohepatitis.