Lipid peroxide 4-HNE, which accumulates during myocardial I/R injury, promotes ubiquitination of GPX4 and induces cardiac ferroptosis by targeting the binding site of GPX4 and ovarian tumor deubiquitinase 5, while activation of aldehyde dehydrogenase 2 to degrade 4-HNE reduces myocardial ferroptosis.805 The transcription factor yes-associated protein (YAP) promotes the transcription of NEDD4L, leading to the ubiquitination and degradation of ACSL4, and reducing cardiac ferroptosis and myocardial infarction size in I/R mice.806. Here, GPX4 is linked to myocardial infarction.