STAT3 and rheumatoid arthritis: The use of antioxidants including selenium, vitamin C, and vitamin E, has shown prospective effects when used to alleviate the symptoms of RA.360 CoQ10 can regulate IL-17 and TH17 via the STAT3 pathway, then inhibit ferroptosis and improve inflammation in joint of RA mice.361 Moreover, anti-inflammatory and the antioxidant effects of natural polyphenols (e.