Reduced intracellular glutathione levels or increased iron concentrations further exacerbate these pathologic phenotypes.590 Furthermore, α-syn oligomers induce lipid peroxidation, while inhibition of lipid peroxidation and reduction of iron-dependent free radical accumulation can reduce the neuronal toxicity induced by α-syn oligomers, suggesting the role of ferroptosis in PD.591,592 A recent study has shown that melatonin receptor 1 (MT1) is involved in α-synuclein induced ferroptosis. The gene discussed is SNCA; the disease is Parkinson disease.