Genetic ablation and/or pharmacological inhibition of FABP5 ameliorate the HCC burden in mice.308 The absence of EF-hand domain family member D2 (EFHD2), improves hepatic steatosis, reduces immune cell infiltration, suppresses ferroptosis caused by lipid peroxidation, and ultimately reduces MASH. This evidence concerns the gene FABP5 and hepatocellular carcinoma.