NCOA4 and osteoarthritis: JTF may protect cartilage by inhibiting ferroptosis and aquaporin dysregulation driven by NCOA4-HMGB1.878 Other active substances in Chinese medicine, such as ruscogenin, curcumin, baicalein, brevilin A, icariin, and cardamonin could also inhibit chondrocyte ferroptosis, reduce cartilage destruction in osteoarthritis.879–885