KLF2 and renal cell carcinoma: Long-distance metastasis is a major obstacle to clinical treatment of RCC.148 Kruppel-like factor 2 (KLF2) is a transcription factor containing conserved zinc finger domains.149 Bioinformatic analysis and immunohistochemical results of clinical samples show that KLF2 expression is reduced in patients with metastatic RCC, and overall survival and metastasis-free survival are shortened in patients with low KLF2 expression.