A member of the RAS superfamily, ADP ribosylation factor 6 (ARF6), acts as a downstream of the KRAS/extracellular signal-regulated kinase (ERK) pathway to increase the proliferation and Warburg effect of pancreatic cancer cells.214 ARF6 negatively regulates ACSL4 expression and regulates gemcitabine resistance by influencing the sensitivity of pancreatic cancer cells to oxidative stress and ferroptosis.214. Here, ACSL4 is linked to familial pancreatic carcinoma.