GPX4 and rheumatoid arthritis: In vitro experiments have shown that GPX4 or FSP1 overexpression protects CD8+ T cells from ferroptosis, while application of GPX4 inhibitor significantly increases the sensitivity of T cells to ferroptosis.353 Interestingly, synovial inflammation is a key event in the RA pathogenesis and a critical trigger for destructions of bone and cartilage.