HIF1A and hyperlipidemia: Echinatin significantly promotes the expression of glutamate cysteine ligase, maintaining the balance of GSH metabolism.277 Scavenger receptor class B type I (SRBI) plays a crucial role in promoting cholesterol efflux from cells and clearing plasma cholesterol, while SRBI deficiency results in disrupted cholesterol metabolism, hyperlipidemia, and subsequent ferroptosis via the HIF-1α/TFR1 pathway.278 The hepcidin-FPN axis is essential for maintaining systemic iron homeostasis Increased serum hepcidin levels are associated with ferroptosis.