Inhibition of LCN2 function by monoclonal antibodies reduces chemotherapy resistance in colon cancer cells and tumors in xenografted mouse models.189 Additionally, the absence of N6-methyladenosine modification results in high expression of cyclin-dependent kinase 1 (CDK1) in oxaliplatin-resistant colon cancer cells and tissues. This evidence concerns the gene CDK1 and colonic neoplasm.