ACSL4 and ischemic stroke: In a rat model of MCAO, RIPostC reverses GPX4 reduction and ACSL4 overexpression by increasing ketone body production, thereby alleviating nerve damage.781 In addition, both RIPostC and ketone bodies reduce total iron and ferrous ion content by inhibiting FPN.781 Bioinformatics analysis showed that CHAC1 is a key gene in the process of ferroptosis in patients with ischemic stroke.