PTGS2 and ovarian cancer: Clinical data show that ACSL1 exhibits a positive correlation with FSP1, while it shows a negative correlation with 4-hydroxynonenal (4-HNE) and prostaglandin-endoperoxide synthase 2 (PTGS2).205 ACSL1 promotes peritoneal metastasis of ovarian cancer cells by reducing lipid peroxidation by lipid reprogramming.