Knockdown of HSPA5 inhibits the migration and invasion of bladder cancer cells by inhibiting the vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor receptor 2 signaling pathway, and overexpression of VEGFA alleviates the effects of HSPA5 downregulation.169 Additionally, overexpression of HSPA5 inhibits ferroptosis through the P53/SLC7A11/GPX4 pathway and may serve as a novel biomarker and potential therapeutic target. Here, HSPA5 is linked to urinary bladder cancer.