TFR2 and Parkinson disease: These major characteristics are strongly aligned with the features of ferroptosis.584,585 Clinical studies have demonstrated a correlation between iron levels in the substantia nigra and PD symptoms, including movement disorders.586 Many PD patients have dysregulated iron regulatory protein expression.587 For example, TF and TFR2 expression are upregulated in dopaminergic neurons in PD brains, and downregulated TFR expression has also been linked to the prevention of dopaminergic neuron degeneration.588,589