NSA2 and chronic kidney disease: This paper describes studies of the 5’regulatory region of the 2 genes NSA2 and GFM2, the increased expression and correlation of the expression of the two genes in human renal biopsy tissue from patients with CKD, and the increased protein content of mitochondrial respiration chain as well as altered mitochondrial respiration in hyperglycaemic renal cells with elevated GFM2 expression.