Similarly, there were more frequencies of intraepithelial IFN-γ-expressing CD4+ T cells (Fig. 5I and Supplementary Fig. 6E) and Granzyme B-expressing CD4+ T cells (Fig. 5L and Supplementary Fig. 6H) in small intestines from Trim29IEC-KO suckling mice than those from Trim29fl/fl mice after rotavirus infection for 3 days. This evidence concerns the gene CD4 and Rotavirus infection.