Next, we further investigated if TRIM29 mediates degradation of NLRP6 and NLRP9b in enteric virus infected intestines in vivo, we inoculated intragastrically Trim29fl/fl and Trim29IEC-KO mice with EMCV or Rotavirus, respectively, and then measured the expressions of TRIM29, NLRP6 and NLRP9b in IECs of small intestines after 2 days of virus infection. The gene discussed is NLRP6; the disease is viral infectious disease.