TRIM29 was upregulated in primary IECs from mouse intestine organoids of Trim29fl/fl mice after EMCV or Rotavirus infection (Fig. 7C and 7D), whereas NLRP6 (Fig. 7C) and NLRP9b (Fig. 7D) were downregulated in mouse IECs from Trim29fl/fl mice after virus infection owing to the degradation by TRIM29. The gene discussed is TRIM29; the disease is Rotavirus infection.