Importantly, compared with Ifnar1−/−–Trim29fl/fl mice, Ifnar1−/−Trim29IEC-KO mice survived much better from EMCV intestinal infection (Fig. 4H), suggesting that the antiviral phenotype of TRIM29 knockout mice results from TRIM29-mediated regulation of type III IFN and inflammasome activation. This evidence concerns the gene TRIM29 and digestive system infectious disorder.