TRIM29 was upregulated in IECs from intestines of Trim29fl/fl mice after EMCV or Rotavirus infection in vivo (Supplementary Fig. 8A), whereas NLRP6 and NLRP9b were downregulated in IECs of intestines from Trim29fl/fl mice after virus infection owing to the degradation by TRIM29 (Supplementary Fig. 8A). Here, NLRP6 is linked to Rotavirus infection.