NLRP6 and Rotavirus infection: Although K63-linked ubiquitination of NLRP6 and NLRP9b was detected in IECs with EMCV or rotavirus infection, which aligns with previous report about K63-linked ubiquitination of NLRP644, there was no difference of K63-linked ubiquitination in mouse IECs from Trim29fl/fl and Trim29IEC-KO mice (Fig. 7F and 7G).