Additionally, although NLRP6 and NLRP9b were barely expressed in human HT-29 IECs, NLRP6 and NLRP9b were induced in HT-29 IECs after EMCV and rotavirus infection (Supplementary Fig. 7A), respectively, suggesting thatNLRP6 and NLRP9b control the upregulation of IFN-λ3 and IL-18 upon knock down of TRIM29. The gene discussed is TRIM29; the disease is Rotavirus infection.