CD4 and infection: However, Trim29IEC-KO adult mice had significantly higher frequencies of intraepithelial IFN-γ-expressing CD4+ T cells (Fig. 5H and Supplementary Fig. 6D) and Granzyme B-expressing CD4+ T cells (Fig. 5K and Supplementary Fig. 6G) in small intestines than Trim29fl/fl mice after EMCV infection for 3 days.