NLRP6 and infection: We found that both NLRP6 and NLRP9b were induced in primary IECs from mouse intestine organoids of Trim29fl/fl mice after infection of EMCV or Rotavirus (Supplementary Fig. 8B), further confirming that NLRP6 and NLRP9b are one of ISG and the degradation of NLRP6 and NLRP9b are mediated by TRIM29.