Previous studies have shown that HIF‐1α can promote the expression of PD‐L1 in cancer cells.[23] To investigate the relationship between the expression of HIF‐2α and PD‐L1 on the cell surface, it was detected that APm/Ce6/HIF+US could reduce the expression of PD‐L1 on the surface of 786‐O cells by FCM (Figure 5G,H). The gene discussed is EPAS1; the disease is cancer.