Previous studies have revealed that SDT can worsen the hypoxic TME and stimulate autophagy in cancer cells.[19] Additionally, studies have also shown that increased expression of HIF‐2α in cancer cells promotes autophagy.[20] To investigate whether APm/Ce6+US could induce the expression of HIF‐2α in renal cancer cells and promote autophagy, the expression of HIF‐2α in 786‐O cells treated with various treatments was examined by western blot. This evidence concerns the gene EPAS1 and cancer.