To investigate the role of HIF‐2α in RCC, the expression of HIF‐2α was measured in various RCC cells, including A498 (human renal cell carcinoma cell), ACHN (human renal adenocarcinoma cell), and 786‐O (human renal adenocarcinoma cell). This evidence concerns the gene EPAS1 and hereditary clear cell renal cell carcinoma.