HMGB1 and cancer: During ICD, cancer cells produce various signaling molecules, including CRT exposed on the cell surface, HMGB1, ATP molecules, and heat shock proteins (HSP70, HSP90).[22] To verify whether APm/Ce6/HIF+US inhibited the proliferation of renal cancer cells via ICD, the expression of CRT on the cell surface in 786‐O cells was measured by immunofluorescence staining.