ANPEP and renal carcinoma: Previous studies have revealed that SDT can worsen the hypoxic TME and stimulate autophagy in cancer cells.[19] Additionally, studies have also shown that increased expression of HIF‐2α in cancer cells promotes autophagy.[20] To investigate whether APm/Ce6+US could induce the expression of HIF‐2α in renal cancer cells and promote autophagy, the expression of HIF‐2α in 786‐O cells treated with various treatments was examined by western blot.