However, there is general agreement that overexpression of p53 and its accumulation in the nucleus indicate that something is wrong in the cell, which is also demonstrated by an interesting result of our meta-analysis: while oral squamous cell carcinoma shows p53 overexpression 2.79-fold higher than in OLP, the overexpression of this protein is 5.70-fold higher in OLP vs. normal oral mucosa, i.e. in relation to p53, OLP closely resembles cancer than normal oral mucosa. The gene discussed is TP53; the disease is cancer.