A research line developed by our group in recent years, applying immunohistochemistry techniques applied to our case series, has reported that essentially a hyperproliferative state develops in OLP with overexpression of ki-67, as well as upregulation of p53 and Bcl-2, and downregulation of caspase-3 and Bax (21-28). Here, TP53 is linked to oral lichen planus.