TNF and periodontal disorder: The presence of comorbidities such as IR characteristic of obese, PCOS and TD2 patients, trigger the release of proinflammatory cytokines such as TNFα that could initially be mediated by a local and systemic proinflammatory environment, which favours a pro-oxidant state, leading to oxidative stress and, finally, irreversible destruction of the periodontal tissue, contributing to pathophysiological mechanisms linking idiopathic infertility and periodontal disease.