In this study, we aimed to apply two-sample MR analysis to investigate the potential causal relationships between endogenous estradiol, bioavailable testosterone, total testosterone, SHBG and risk of lung and colorectal cancers in women of European ancestry: in The Trøndelag Health Study (HUNT) in Norway, the International Lung Cancer Consortium (ILCCO), FinnGen and three large consortia of colorectal cancer. Here, SHBG is linked to colorectal cancer.