HSD17B11 has been shown to associate with lipid droplets in Huh7 and VA-13 (human hepatoma cells) as well as HeLa cells, and overexpression of HSD17B11 increases the size of lipid droplets in VA-13 and HeLa cells, possibly through reduced adipose triglyceride lipase translocation to the lipid droplets (81, 82, 83). This evidence concerns the gene PNPLA2 and hepatocellular carcinoma.