We detected a significant positive correlation between HSD17B11 mRNA expression in human liver biopsies and the hepatic fat content analyzed by magnetic resonance spectroscopy as well as the severity of MASH assessed by MAS (i.e., histological scores of liver steatosis, inflammation, and ballooning) and hepatic fibrosis stage as recommended by the MASH Clinical Research Network (40) (supplemental Fig. S11 and, supplemental Table S2). Here, HSD17B11 is linked to metabolic dysfunction-associated steatohepatitis.