Interestingly, the best-characterized genetic risk factors controlling the susceptibility to MASLD—PNPLA3, HSD17B13, PLIN2 (also known as ADPR and adipophilin), and MBOAT7—encode proteins anchored to the hepatocellular lipid droplets (9, 12). Here, PLIN2 is linked to metabolic dysfunction-associated steatotic liver disease.