A significant reduction in signatures representing genomic instability (Figure 2F; P < 0.001) and senescence (Figure 2G; P < 0.001) was also observed as well as an increase in transforming growth factor (TGF)-β signalling (Figure 2H; P < 0.001), which is proposed to drive immune evasion and the exclusion of T cells from the tumour microenvironment (TME).31 Here, TGFB1 is linked to neoplasm.