CXCL5 and neoplasm: In keeping with the GSEA results, the top ranked differentially expressed gene associated with tumour response was the inflammatory chemokine CXCL5, which has a key role in immune cell, particularly neutrophil, accumulation in tumours (Figure 4E and Supplementary Table S14, available at https://doi.org/10.1016/j.esmoop.2024.103930).33